January, 2023 - Japanese Journal of Gastroenterology and Hepatology

Self-expandable Metallic Stents for the Palliation of Malignant Growth of Esophagus

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1. Abstract 1.1. Background: Often patients with carcinomas of esophagus presents with dysphagia at a late stage where curative treatments are not a treatment option. To relieve dysphagia and its consequences palliative esophageal stentings are offered. Self-expanding metal stents (SEMS) and self-expanding plastic stents (SEPS) are available for reliving the dysphagia. Uncovered, partially covered, or …

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A Rare Case of Primary Cystic Duct Adenocarcinoma

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1. Summary Primary cystic duct adenocarcinomas is rare amongst the extrahepatic bile duct malignancy. Moreso it has a very difficult preoperative diagnosis and is diagnosed intraoperatively or postoperatively. It has a better prognosis compared to other extrahepatic biliary tumours. We describe a case which was preoperatively diagnosed as carcinoma neck of gall bladder, intraoperatively showing …

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Intrahepatic Portal Hypertension Syndrome Secondary to Primary Myelofibrosis: About A Case

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1. Summary In primary myelofibrosis (PM), it is rare to observe PH by intrahepatic block secondary to hepatic myeloid metaplasia. Its diagnosis is histological based on liver biopsy. Splenomegaly and hepatomegaly are the main signs found at the beginning of the disease, while ascites and digestive hemorrhage are complications that cloud the prognosis. The etiological …

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A large Gastric Diverticulum: A Rare Endoscopic Finding

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1. Abstract 1.1. Introduction: A gastric diverticulum is a rare form of diverticular disease due to outpouching of the gastric wall. The rates of detection vary depending upon the method used to detect them. Occasionally, complications, such as ulceration, upper gastro intestinal bleeding, hemorrhage, perforation, and malignant transformation, can develop that may be life-threatening and …

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Effects of Targeting NRF2 on Inhibiting Gastric Cancer Growth and Tumor Development in Vitro and in Vivo

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1. Abstract 1.1. Background: Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a transcription factor that regulates the expression of the cellular antioxidant response. Traditionally, Nrf2 is regarded as a tumor suppressor owing to its characteristic which prevents oxidative or electrophilic insult. However, there is increasing evidence that Nrf2 is activated in malignant cells. At …

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