Hepatitis B Virus X Protein and Hepatitis C Virus Core Protein Cooperate to Inhibit P16 Expression Via DNA Methylation
1. Abstract Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is often associated with a higher risk of hepatocellular carcinoma (HCC). Here, we found that HBV X protein (HBx) and HCV core protein cooperate to inhibit p16 expression via DNA methylation in human hepatoma cells. For this purpose, they additively upregulated both …