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Persistent Elevation of Serum Prothrombin Induced by Vitamin K Deficiency or Antagonist Despite Discontinuation of Warfarin Administration in Alcoholic Cirrhosis in The Absence of Hepatocellular Carcinoma: A Case Report

1. Abstract Whereas serum prothrombin induced vitamin K deficiency or antagonist II (PIVKA-II) is a di- agnostic and prognostic marker of hepatocellular carcinoma (HCC), the serum PIVKA-II level rarely increases in chronic liver diseases in the absence of HCC. Although warfarin administration induces marked elevation of PIVKA-II, warfarin discontinuation may lead to swift normalization of …

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SARS-CoV-2 originated from laboratory?

1. Letter to Editor The Corona Virus Disease 2019(COVID-19) could be a viral respiratory disorder that caused by a new coronavirus called SARS-CoV-2 [1]. Severe acute respiratory syndrome coronavirus (SARS- CoV) and Middle East respiratory syndrome coronavirus (MERS- CoV) are two pathogenic viruses in humans. Both SARS?CoV and MERS?CoV are zoonotic in origin and both …

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Pediatric Pancreatic Hemangioma

1. Clinical ImageA 5 year old girl had a pancreatic mass. Resection reveals a circumscribed lobulated mass in pancreas with greyish brown color. The mass are composed of vascular structures re- sembling veins and capillary-sized vessels. Endothelial lining cells are flattened with bland looking nuclei. While the remaining pancreas tissue is unremarkable (Pic A, original …

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Uncommon Cause of Gastrointestinal Bleeding

1. Introduction Gastric antral vascular ectasia is an uncommon cause of chronic gastrointestinal bleeding or iron deficiency anaemia [1]. The condition is associated with dilated small blood ves- sels in the antrum, or the last part of the stomach. It is also called watermelon stomach because streaky long red areas that are present in the …

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Mutation at Codon 249 of the TP53 Gene in Hepatocellular Carcinoma: MD-CT and Pathologic Features

1. Abstract Aflatoxin B1 is a mycotoxin produced by the Aspergillus Flavus fungus that contaminates many sources of food. This mycotoxin has its metabolism into the liver. So, Aflatoxin B1 metabolites create a DNA mutation at the third base of codon 249 in the TP53 tumor suppressor gene, inducing a G to T trasversion (AGG …

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High-Dose Methotrexate, A Tried-and-True Treatment with Genomic Delicacies: A Case Report

1. Abstract The prediction of methotrexate (MTX) adverse events has been a challenge to the clinician; here we present a case of toxicity after the previous exposition with the development of hepatic, renal, and hematologic toxicity. The development of methotrexate toxicity has been previously analyzed in our institution, where a significant percentage of the patients …

High-Dose Methotrexate, A Tried-and-True Treatment with Genomic
Delicacies: A Case Report
Read More »

Predictive Factors of Bowel Resection Due to an Incarcerated Groin Hernia

1. Abstract 1.1. Purpose: In this retrospective study, we assessed factors that can be used to predict the need for bowel resection due to an incarcerated groin hernia. 1.2. Methods: We enrolled a total of 83 patients diagnosed with an incarcerated groin hernia on preoperative unenhanced Computed Tomography (CT) between January 2010 and December 2019 …

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Gut-Liver Axis Modulation: A Potential Role of Probiotics and Omega-3 Fatty Acids in Management of NAFLD

1. Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) has currently emerged as common liver disorder com- pared to alcoholic liver disease. The prevalence of NAFLD in India varies from 9% in rural areas to 32% in urban populations. This incidence is reported to be the lowest in western India (44.1%) compared to the highest prevalence in …

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Emergency Care Sick Palliative and Problems Oncology in Emergency Department during the Covid-19 Pandemic

1. Abstract Emergency medical care in palliative patients during the COVID-19 pandemic, it is important to provide a consistent treatment for stable patients that should be consistent with the goals and benefits, the perspective of these patients, but avoiding palliative patients with a poor prognosis that is unlikely to survive. Cancer is the second leading …

Emergency Care Sick Palliative and Problems Oncology in Emergency
Department during the Covid-19 Pandemic
Read More »

Principles of Cryopreservation and Applicabilities in Intestinal Organoids

1. AbstractCryobiology is known as a study of low temperatures effects in tissues and cells, which means understand influences on decreasing temperature and pressure in the freezing medium and how the cell membrane reacts to these variables. Cryopreservation emerged by the principles of Cryo- biology as a technology capable of preserving the composition and viability …

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