Issue 1 Articles

Endoscopic Management of Esophageal Foreign Bodies: A Retrospective Study in China

1. Abstract Esophageal Foreign Bodies (FBs) are the common clinical emergency, accounting for 4% of emergency endoscopic diagnosis and therapeutic approach. Approaches to handle these cases are evolved continuously and offered better treatment with less cost, reduced surgery, improved visualization with high success rate. Clinically data are lacking to choose the better method and whether …

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The General Public’s Perceptions, Attitudes and Treatment Intentions of Irritable Bowel Syndrome: A Questionnaire Survey

1. Abstract Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder with a high prevalence rate, which affects the quality of life (QOL) and psychological health of patients to varying degrees. To understand the perceptions, attitudes, and treatment intentions of IBS among the general public, we conducted a questionnaire survey on IBS.

Involvement of Claudin-1 in Thrombin Promoting Airway Remodeling in Asthma

1. Abstract Claudin-1 is an important member of the cellular tight junction protein, which is very important to barrier function. But some studies have shown that Claudin-1 is associated with cell proliferation, so its role in asthma gets more and more attention. Asthma is associated with clotting system in the lungs. Thrombin is thought to …

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Rarely Seen Duodenal Varices Merit Vigilant Endoscopy

1. Abstract 1.1. Case Report: We present a thirty year old female who was diagnosed recently to be suffering from cryptogenic related compensated chronic liver disease. She had no history of ascites, pedal edema, upper or lower gastrointestinal bleed or Porto systemic encephalopathy. On evaluation her complete haemogram revealed mild anemia and thrombocytopenia, liver function …

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NAFLD Patients have Limited Access to GLP1 Agonists and SGLT2 Inhibitors: NHANES-Transient Elastography 2017-2018

1. Abstract 1.1. Background and Aims: This study analyzed medications among NAFLD (controlled attenuation parameter ≥302 dB/m) ± diabetes or advanced fibrosis (AF, stiffness ≥9.7 kPa). 1.2. Method: 2017-2018 NHANES data were analyzed. Exclusion criteria were age<18, high alcohol consumption (≥7/14 drinks/week for females/males, respectively), or viral hepatitis. 1.3. Results: Of 3,899, 26.3% had NAFLD, …

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Changes of Plasma Biomarkers in Patients with Chronic Liver Diseases Predict Liver Cell Death

1. Abstract 1.1. Background: We evaluated the changes of biomarkers and their significance in patients with nonalcoholic fatty liver disease. 1.2. Methods: One hundred and ten nonalcoholic fatty liver disease patients were enrolled into experimental group and one hundred and ten healthy people into control group. The plasma levels of biomarkers were detected. 1.3. Results: …

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Research Progress of Intestinal Flora and High Fat Diet Obesity

1. Abstract Obesity is a chronic metabolic disorder caused by an energy imbalance, which is becoming an increasingly prevalent and ubiquitous problem worldwide. Its cause is complex, including genetic factors, high fat diet, intestinal tract bacterium group. The effect of intestinal flora on obesity has been widely recognized in the past few years. This article …

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Endocuff-Assisted Colonoscopy Demonstrates High Ileal Intubation and Adenoma Detection Rates in Trainees

1. Abstract 1.1. Introduction: The Endocuff (EC) significantly improves the Adenoma Detection Rate (ADR). Whereas cecal intubation and cost-effectiveness using the EC have been studied repeatedly, evidence regarding the Ileum Intubation Rate (IIR) remains scarce. This study investigates the IRR and ADR in EC-assisted colonoscopy compared with standard colonoscopy in patients undergoing screening and/or surveillance …

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Primary Murine Hepatocyte Isolation and Culture with GMP and Research-Grade Enzyme Blends

1. Abstract Hepatocyte transplantation for acute liver failure and metabolic liver disorders represent a potential alternative to traditional orthotopic liver transplantation (OLT). Additionally, cultured primary hepatocytes are an important tool for in vitro pharmacological studies. Advances in clinical hepatocyte transplantation and drug studies depend on the development of standardized isolation and culturing protocols as well …

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