No Significant Liver Disease or True Immune-tolerant HBeAg Positive Chronic Hepatitis B with Normal Serum ALT Levels

1.1. Background Hepatitis B e antigen (HBeAg)-positive Chronic hepatitis B (CHB) patients with normal alanine aminotransaminase (ALT) were usually considered to be in the immune-tolerant phase. However, it has been suggested that the current upper limit of normal for ALT should be lowered.