Research Article

Synthesis, Characterization, Biological Evaluation of Some Heterocyclic Oxazepine Derivatives

1. Abstract The new serious of pentyloxy and aryloxy benzaldehyde (3ae) were synthesized from the substitution reaction of 4-hydroxy benzaldehyde with different aryl bromide and alkyl bromide, on the basis of Williamson ether synthesis in the presence of Potassium carbonate using absolute ethanol as a solvent. The second step was the synthesis of 2-amino-5-(p-tolyl)1,3,4-thiadiazole. DOI:http://dx.doi.org/10.47829/JJGH.2021.62201

Mixing of Sputnik V and Astrazeneca COVID-19 Vaccines

1. Abstract The coronavirus disease 2019 (COVID-19) vaccine helps to develop immunity to SARS-CoV-2, the virus that causes COVID-19, in most cases preventing the disease. Although various brands of vaccines work in different modes, all COVID-19 vaccines prompt an immune reaction to make the body remembers how to protect from the virus in the future. …

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Increased Expression of GNL3L is Associated with Aggressive Phenotypes in Colorectal Cancer

1. Abstract 1.1. Background and Objective: Guanine nucleotide binding protein-like 3-like (GNL3L) plays critical roles in development and progression of several types of human cancers. However, the function and clinical significance of GNL3L in colorectal cancer (CRC) remain unclear. In this study, the effect of GNL3L in CRC and its underlying mechanism were investigated. DOI:http://dx.doi.org/10.47829/JJGH.2021.62103

Review of Esophagectomy Side Effects

1. Abstract The primary indication for an esophagectomy is esophageal cancer or Barrett’s esophagus with high-grade dysplasia. Patients undergoing esophagectomy often present with dysphagia, side effects from chemotherapy, decreased appetite, and weight loss. Esophagectomy may be an operation involving the abdomen, neck, and/or chest requiring 5 to 7 days of NPO status to permit healing …

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Need of Dual Antiviral Treatment in Chronic Hepatitis B

1. Abstract 1.1. Introduction: Approximately one third of the world’s population has serological evidence of past or present infection with the hepatitis B virus (HBV). An estimated 350-400 million people are surface HBV antigen (HBsAg) carriers. India has 40 million HBV carriers i.e. 10–15% share of total pool of HBV carriers of the world. In …

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Eosinophil Cationic Protein Can Monitoring Efficacy of Specific Immunoterapy in Eosinophilic Esophagitis

1. Abstract 1.1. Background: Eosinophil Cationic Protein (ECP) has proven a useful monitor for many active eosinophilic inflammatory diseases. In the last years we have successfully treated patients suffered from eosinophilic esophagitis whit Allergen Specific Immunotherapy (AIT) and diet guided by Component-Resolved Diagnosis (CRD), that could detect possible allergens involved in eosinophilic esophagitis (EoE). DOI:http://dx.doi.org/10.47829/JJGH.2021.61901

Chronic HCV in CKD-Experience with Oral Antiviral at Tertiary Care Centre of Northern India

1. Abstract 1.1. Introduction: Chronic hepatitis C is one of the most common cause all over the world for causing cirrhosis of liver. It is commonly seen in Chronic Kidney Disease (CKD) patients who are on maintenance dialysis and treatment with oral directly acting antiviral is challenging due to renal side effects of sofosbuvir which …

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Post Covid-19 Complications After First Wave in Haryana

1. Abstract 1.1. Introduction: Covid-19 is an ongoing global pandemic around the world which has led to devastation both with human lives as well as economy. The agony of patients who get infected with this deadly virus, does not end with recovery from it, as many face Post Covid-19 complications. There is very limited data …

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