Research Article

Epidemiological Characteristics of De Novo Hepatitis B Infection in Liver Transplant Recipients – An Experience from a Tertiary Care Centre in Qatar

Emergence of Hepatitis B Surface Antigen (HBsAg) in a patient with previously negative Hepatitis B Virus (HBV) serology post Orthotropic Liver Transplant (OTLX) is known as De-novo Hepatitis B (DNHB). To study the clinical profile and epidemiology of patients with DNHB in Qatar. This descriptive epidemiological study was done by retrospectively reviewing records of 159 …

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A Hepatocelluar Co-Culture System for the Investigation of Cellular-Based Mechanisms of Troglitazone-Induced Liver Injury

Drug-induced liver injury (DILI) is a serious issue faced by the pharmaceutical industry, and often leads to drug withdrawal once patients experience drug-induced severe hepatic failure. We developed an in vitro assay system that enables to assess cellular damage and immune reaction responses that ultimately result in DILI using troglitazone as a model drug….

Prognostic Variables for Patients with T2N0M0 Esophageal Squamous Cell Carcinoma

To explore the variables which could predict the prognosis and might be considered as staging factors in patients with T2N0M0 Esophageal Squamous Cell Carcinoma (ESCC).Records of 525 patients with pathologic T2N0M0 ESCC who underwent surgical resection were reviewed. The T2 category was further subdivided into T2a (circular muscle layers) and T2b (longitudinal muscle layers)….

Immunological Pathways in the Development of Postoperative Hyper- amylasemia and Postoperative Pancreatitis

Postoperative pancreatitis complications can be separated into two main groups based on literature reviews and clinical trials. Some authors suggest that postoperative pancreatitis is a severe complication that should be treated conservatively and operatively if needed. Other authors defend an opposite opinion that only postoperative hyperamylasemia exists, which is a transitory condition with no risk …

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Prevalence of Nocturnal Leg Cramps in Patients with Liver Disease is Higher than with Other Chronic Disease

A nocturnal leg cramps (NLC) is caused by a continuous, involuntary, painful, and localized contraction of a muscle or simply some muscle bundles.NLC is associated with a reduced quality of sleep and a subsequent lower health related quality of life. The purpose of our study is to clarify both prevalence and characteristics of NLC in …

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The Relationship between Pancreatic Fibrosis and Pancrea- tic Cell Apoptosis Induced by Fas/Fas Ligand Pathways in Aly/Aly Mice

In this study, we examined the relationship between the expression of Fas/Fas ligand apoptotic signaling pathway and pancreatic fibrosis in autoimmune chronic pancreatitis of aly/aly mice. The histopathological changes of inflammatory cell infiltration in pancreatitis aly/ aly mice were observed. Immunohistochemistry was used to detect the expression of CD4, CD8, CD45R/B220, F4, Fas/Fas ligand, collagen …

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