Research Article

1. Abstract 1.1. Background: Yindan Pinggan Capsule, a patent Chinese medicine, has a definite effect on Yang Huang syndrome. At present, the pharmacological activity and quality control of Yindan Pinggan Capsule have been studied, but its effective constituents on the treatment of Yang Huang syndrome are still unclear.

1. Abstract 1.1. Background: The burden of Gastroesophageal reflux disease is high among the Saudi population. Various defense mechanisms play a role in preventing GERD, and the usefulness of manometry in identifying them has not been studied well in Saudi Arabia.

1. Abstract 1.1. Background: Bcylcholinesterase (BCHE) is a nonspecific esterase synthesized by the liver that promotes cell proliferation and differentiation. Several studies suggested that BCHE is related to the occurrence and development of some tumors. However, the expression of BCHE in stomach adenocarcinoma (STAD) and its regulatory mechanism remains elusive.

1. Abstract 1.1. Background/Purpose: Endoscopic management with self-expandable metallic stents (SEMSs) for advanced malignant gastroduodenal obstruction is widely used, however stenting in patients with malignant distal duodenal obstruction (MDDO) is challenging because of the length and flexibility of the endoscope, the curved configuration of the duodenal C-loop, and the angle of the duodenojejunal flexure. Studies …

Comparable Outcomes of Uncovered Metallic Stents and Partially Covered Metallic Stents in Malignant Distal Duodenal Obstruction Read More »

1. Abstract 1.1. Introduction: Anticancer drug insensitivity/resistance is a bottleneck in the treatment of gastric cancer. To overcome this challenge, we evaluated the clinical utility of an in-vitro collagen gel droplet embedded culture drug sensitivity test (CD-DST) using patient-derived gastric cancer tissues for personalized treatment guidance. 1.2. Methods: We collected the surgically removed fresh tumor …

Clinical Predictive Value of CD-DST for the Efficacy of Postoperative XELOX Adjuvant Chemotherapy in Advanced Gastric Adenocarcinoma Read More »

1. Abstract 1.1. Background: The blood is a life saving component which cannot be produced but has to donated by healthy donors. In view of high Seroprevalence of transfusion-transmitted infectious diseases such as HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in India which affects the safety of blood for recipients, mandatory …

Tele Counseling -Effective Strategy for Blood Donors with Chronic Hepatitis B and C Read More »

1. Abstract 1.1. Background: There is a dearth of population-based evidence regarding the role of surgery in the treatment of patients with small gastrointestinal stromal tumors (sGISTs)(<2cm). The purpose of this study was to describe the demographic features and investigate the impact of surgery treatment on survival outcome in patients with sGISTs.

1. Abstract 1.1. Aims DBPR108 is an orally active dipeptidyl peptidase 4 (DPP-4) inhibitor in animals. The present first-in-human randomized, double-blind, and placebo-controlled study evaluated DBPR108 for safety and tolerability in healthy adult Asian male volunteers. 1.2. Main Methods DBPR108 were orally given at 25-600 mg as single and multiple once-daily doses for 8 consecutive …

DBPR108, A Dipeptidyl Peptidase-4 Inhibitor for Treatment of Type 2 Diabetes Mellitus: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Single and Multiple Doses in Healthy Volunteers Read More »

1. Abstract 1.1. Objectives: Pyroptosis is a type of programmed cell death that has been discovered and confirmed in recent years, which were characterized by pro-inflammatory and is related to tumor progression, prognosis and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear. At the same time, …

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration Read More »

1. Abstract 1.1. Background: Constipation is a common condition. Lactulose & Polyethylene Glycol (PEG) are effective & safe, recommended as first-line medication for Chronic Constipation (CC). 1.2. Aim: To compare the efficacy and safety of PEG 3350 versus lactulose in patients with CC. 1.3. Methods: In this single-center, randomised, open label, parallel-group study. Patients with …

Comparative Efficacy and Safety of Polyethylene Glycol vs Lactulose in Chronic Constipation: Non Inferiority Study Read More »