Month: February 2022

Circulating Exosomal Micrornas as Prognostic Biomarkers in Cholangicarcinoma: A Systematic Review

1.Abstract 1.1. Introduction: Cholangiocarcinoma (CCA) is a cancer that arises from the cells within the bile ducts; both inside and outside the liver. Exosomal microRNAs (miRNAs) have been attracting major interest as potential biomarker in cancer. Our aims to do a systematic review on exosomal miRNAs serve as candidate clinical biomarkers in CCA. 1.2. Materials …

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Impact of Plasmodium Falciparum Malaria on Liver and Red Blood Cell

1. Abstract Malaria remains one of the greatest public health challenges worldwide, particularly in tropical and sub-tropical countries. Estimates about 212 million and 429.000 death per year worldwide. The liver and Red Blood Cell (RBC) are the organ that has clearly changed in the early stages of infection. The aim of this study was to …

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Irritable Bowel or Irritable Brain? Cognitive Behavioural Therapy for Irritable Bowel Syndrome: A Review and Recommendations for Clinical Practice

1. Abstract Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disorder commonly seen in general practice. IBS has been described as a disturbance of the brain-gut axis where psychological stressors, such as stressful life events and anxiety, may affect the onset and development of this condition. Despite the availability of different management options, current treatments …

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Monitoring of Resistant-Related Genes to Cetuximab in Extracellular Vesicle-Derived DNA from Metastatic Colorectal Cancer Patients

1. Abstract 1.1. Background: Extracellular vesicle derived-DNA (EV DNA) have emerged as attractive diagnostic biomarkers in diseases diagnosis, while its role in metastatic colorectal cancer (mCRC) is unknown. This study aimed to explore the role of EV DNA in monitoring of gene mutations related to drug resistance during therapy with the anti-EGFR antibody cetuximab.

Hematological Changes post Bariatric Surgery in Saudi Arabia; Single Tertiary Care Center Experience

1. Abstract 1.1. Background: Bariatric surgery is considered a life-saving intervention for treating morbid obesity. The overall reduction in caloric intake accompanied by reduced intake of proteins and several key nutrients, such as iron and vitamin B12 can severely affect various hematological markers, including hemoglobin, hematocrit, and RBC count. This study aimed to investigate the …

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Measure Twice, Cut Once: Appraising The Safety of ERCP in IBD

1. Abstract 1.1. Background: Advanced endoscopy, namely endoscopic retrograde cholangiopancreatography (ERCP), has an integral role in the diagnosis and management of patients with Inflammatory Bowel Disease (IBD). ERCP is frequently performed in this population to diagnose Primary Sclerosing Cholangitis (PSC) or to manage strictures. This study aims to evaluate ERCP-related AEs in IBD patients using …

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Pros and Cons of Iron Deficiency and Iron Deficiency Anaemia

1. Short Communication Iron deficiency anaemia (IDA) and iron deficiency (AD) are very common specially in low-income countries [1]. People can suffer from symptoms of anaemia in the absence of anaemia itself if they have decreased iron stores as red blood cells and tissue will not receive enough iron from the plasma when iron stores …

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