Mutation at Codon 249 of the TP53 Gene in Hepatocellular Carcinoma: MD-CT and Pathologic Features
1. Abstract Aflatoxin B1 is a mycotoxin produced by the Aspergillus Flavus fungus that contaminates many sources of food. This mycotoxin has its metabolism into the liver. So, Aflatoxin B1 metabolites create a DNA mutation at the third base of codon 249 in the TP53 tumor suppressor gene, inducing a G to T trasversion (AGG …