Issue 12

Mutation at Codon 249 of the TP53 Gene in Hepatocellular Carcinoma: MD-CT and Pathologic Features

1. Abstract Aflatoxin B1 is a mycotoxin produced by the Aspergillus Flavus fungus that contaminates many sources of food. This mycotoxin has its metabolism into the liver. So, Aflatoxin B1 metabolites create a DNA mutation at the third base of codon 249 in the TP53 tumor suppressor gene, inducing a G to T trasversion (AGG …

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High-Dose Methotrexate, A Tried-and-True Treatment with Genomic Delicacies: A Case Report

1. Abstract The prediction of methotrexate (MTX) adverse events has been a challenge to the clinician; here we present a case of toxicity after the previous exposition with the development of hepatic, renal, and hematologic toxicity. The development of methotrexate toxicity has been previously analyzed in our institution, where a significant percentage of the patients …

High-Dose Methotrexate, A Tried-and-True Treatment with Genomic
Delicacies: A Case Report
Read More »

Predictive Factors of Bowel Resection Due to an Incarcerated Groin Hernia

1. Abstract 1.1. Purpose: In this retrospective study, we assessed factors that can be used to predict the need for bowel resection due to an incarcerated groin hernia. 1.2. Methods: We enrolled a total of 83 patients diagnosed with an incarcerated groin hernia on preoperative unenhanced Computed Tomography (CT) between January 2010 and December 2019 …

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Gut-Liver Axis Modulation: A Potential Role of Probiotics and Omega-3 Fatty Acids in Management of NAFLD

1. Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) has currently emerged as common liver disorder com- pared to alcoholic liver disease. The prevalence of NAFLD in India varies from 9% in rural areas to 32% in urban populations. This incidence is reported to be the lowest in western India (44.1%) compared to the highest prevalence in …

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