Persistent Elevation of Serum Prothrombin Induced by Vitamin K Deficiency or Antagonist Despite Discontinuation of Warfarin Administration in Alcoholic Cirrhosis in The Absence of Hepatocellular Carcinoma: A Case Report
1. Abstract Whereas serum prothrombin induced vitamin K deficiency or antagonist II (PIVKA-II) is a di- agnostic and prognostic marker of hepatocellular carcinoma (HCC), the serum PIVKA-II level rarely increases in chronic liver diseases in the absence of HCC. Although warfarin administration induces marked elevation of PIVKA-II, warfarin discontinuation may lead to swift normalization of …
