Research Article

Potential of Absorption, Capillary Effect and Sponge-Effect in Endoscopic-Assisted Therapy for Leaks and Fistulas

1. Abstract 1.1. Introduction: Anastomotic leaks and fistulas as well as perforations do lead to increased morbidity and mortality. Several interventional endoscopic techniques such as stents, clips, endoscopic suturing and endoscopic vacuum therapy, can help in reducing an unfavorable outcome of these patients, using a differentiated management of leakages. An important feature of these therapeutic …

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Primary Fistulotomy and Surgical Drainage Abscess is Associated with Low Fistula Recurrence Rate

1. Abstract 1.1. Background: Anorectal abscesses have become a common surgical problem, approximately one third of them also have anal fistulae; management can be conservative with antibiotics or needle aspiration and simple drainage with local anesthesia, considering them sufficient to remit the acute condition of this pathology. However, this line of treatment has been associated …

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In-Hospital Mortality of Patients with Liver Failure: A Propensity Score Matched Cohort Study

1. Abstract 1.1. Background: Model for End-stage Liver Disease (MELD) has been considered as a poor prognostic indicator for patients with liver failure in most previous studies, however, some studies suggest that MELD is not ideal in clinical application. Therefore, new studies on MELD and poor outcomes in patients with liver failure are still necessary. …

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Transjugular Intrahepatic Portosystemic Shunt Infection: A Case Study of Bacteraemia caused by Escherichia Coli

1. Abstract 1.1. Background It is widely believed that liver transplantation is the only way to cure hepatic cirrhosis. However, due to limited funds and liver donors, liver transplantation is seldom performed in Asia, especially in China. For patients who have experienced oesophageal and gastric varices bleeding and waiting for a liver transplant, transjugular intrahepatic …

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Efficacy of Pemafibrate Against Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

1. Abstract 1.1. Background: Nonalcoholic fatty liver disease (NAFLD), one of the most common causes of chronic liver diseases, is characterized by chronic liver inflammation and fibrosis, which consequently promote cirrhosis and liver cancer. Pemafibrate, a selective PPARα modulator is a new lipid-lowering drug that provides better hypertriglyceridemia control compared to greater other fibrates without …

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Immunological Reason for Mild Affection of Children to COVID-19, A Key Factor for Novel Solution of Vaccination and Medications

1. Abstract Coronaviruses are important human and animal pathogens. We will show that probably antibodies don’t have essential role in immunity against COVID-19 in long term, but a type of white globules named T cells may have critical role in immunity against COVID-19. T cells have long time memory to remain in blood.

Microrna-145 Inhibits EMT and Fibrosarcoma Cell Proliferation, Migration and Invasion by Targeting HMGA2

1. Abstract 1.1 Aim: Fibrosarcoma is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth and a high rate of local recurrence. The participation of microRNAs (miRNAs/miRs) in the pathogenesis of human diseases and the vital role of miR-145 in different types of cancer. However, the role of miR-145 in fibrosarcoma remains …

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