Research Article

Sorafenib-Induced Exosome Secretion Promotes Chemotherapy Resistance in Hepatoma Cell Line

1. Abstract Hepatocellular Carcinoma (HCC) is a most common cause of cancer- related deaths globally. Traditional HCC treatments, including surgery, radiation therapy, and chemotherapy, could provide potential options; however, Sorafenib has been used for advanced HCC treatment. Unfortunately, most patients with advanced-stage HCC do not benefit from Sorafenib for its easy progression to resistance. Although …

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The Prevalence of Depression and Its Association with Prior Opioid Use Among Patients in an Outpatient IBD Program

1. Abstract 1.1. Background: Depression is a common comorbidity in chronic medical conditions including inflammatory bowel disease (IBD) and is a major determinant of health-related quality of life (HR-QOL). IBD patients often also experience chronic pain, and hence this population has significant opioid use. The aim of this study is to determine the prevalence of …

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Pancreatic Neuroendocrine Tumors: The Experience of The “A” Visceral Surgery Department in The Light of the New Who 2017 Classification

1. Abstract 1.1. Introduction: PNETs represent 1-5% of all NET and about 1% of pancreatic tumors. The object if of this study is to firstly introduce the update of the new WHO 2017 classification and to report epidemiological, clinical, paraclinical, therapeutic, anatomopathological and evolutive characteristics of cases of PNETs treated in our service.

Impact of Helicobacter Pylori Treatment Failure On Long-Term Clinical Outcomes in Patients with Atrial Fibrillation

1. Abstract There was limited data about the association between the Helicobacter pylori(H.pylori) and AF in the long-term follow up. We evaluated the impact of H.pylori treatment failure on long-term clinical outcomes with AF. The echocardiography, electrocardiogram and H.pylori database were reviewed from 2017-19 to identify patients with AF and H. pylori. Among 701 patients …

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Nutritional Myths and Challanges in Celiac Disease

1. Abstract 1.1. Background: Celiac Disease (CD) is a common chronic immune- mediated, inflammatory disorder of the small intestine induced by a permanent intolerance to dietary wheat, barley, and rye. 1.2. Discussion: Celiac disease has a multifactorial pathogenesis and common symptoms may include bulky stool, constipation, anemia, delayed growth, failure to thrive and infertility. At …

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Incidence of Infectious Events in Patients with Inflammatory Bowel Disease. The Impact of Treatment with Immunomodulators and Biologics

1. Abstract 1.1. Background and Aim: To analyse the incidence of infectious events in patients with inflammatory bowel disease (IBD) and the association to concomitant medical therapy for IBD. 1.2. Methods: We performed a retrospective medical chart review of patients with inflammatory bowel disease age 18-65 years included in the Swedish Registry of Inflammatory Bowel …

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