Research Article

Hepatitis B Virus X Protein and Hepatitis C Virus Core Protein Cooperate to Inhibit P16 Expression Via DNA Methylation

1. Abstract Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is often associated with a higher risk of hepatocellular carcinoma (HCC). Here, we found that HBV X protein (HBx) and HCV core protein cooperate to inhibit p16 expression via DNA methylation in human hepatoma cells. For this purpose, they additively upregulated both …

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Assessment of Muscle and Fat Mass in Type 2 Diabetes Patients By Dual-Energy X-Ray Absorptiometry

1. Abstract 1.1. Background: The aim of this study was to assess the quantitative composition of muscle and adipose tissue in type 2 diabetes mellitus (T2DM) patients on the basis of dual-energy X-ray absorptiometry for the diagnosis of obesity and sarcopenia. 1.2. Methods: Dual-energy X-ray absorptiometry was administered to 50 patients with T2DM. Evaluation of …

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Colon Versus Rectal Cancers among Surgical Approach: An Observational Study

1. Abstract 1.1. Background: Colorectal cancer is the most common tumor of the gastrointestinal tract, and it is the third leading cause of mortality throughout the world. 1.2. Objectives: An observational study of colorectal cancers. 1.3. Methods: The research was carried out in Abu Ghraib General hospital in the period from January 2019 to May …

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Clinical Outcomes of Mass-Forming Intrahepatic Cholangiocarcinoma: A Case Series of 68 Patients

1. Abstract 1.1 Background: This study aims to examine the prognostic factors of patients with MF ICC in order to improve the outcomes of ICC. 1.2. Methods: We carried out a retrospective analysis of consecutive patients with MF ICC treated at the Faculty of Hepato-Pancreato-Biliary Surgery of Chinese PLA General Hospital between January 2008 and …

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Predictive Factors of Decompensation and Death in 670 Patients with Hepatitis C Treated with Direct-Acting Antivirals

1. Abstract Sustained virological response 12 weeks after treatment (SVR12) with direct-acting antivirals (DAAs) is excellent in patients with hepatitis C but little has been published regarding decompensation and/or death during therapy. 1.1. Objectives: Objectives of this prospective, observational, multicenter study were to describe SVR12 in real life patients with advanced fibrosis/cirrhosis treated with DAAs …

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Spectrum of Acute Hepatitis B at Tertiary Care Center of Northeren India

1. Abstract 1.1. Introduction: Hepatitis is often a viral infection and Hepatitis B Virus (HBV) is reason in significant proportion of cases worldwide. Hepatitis B virus impact on liver can be of varying severity ranging from acute hepatitis to chronic hepatitis which can further lead to chronic liver disease, liver cirrhosis and hepatocellular carcinoma (HCC). …

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Role of Serum Nitric Oxide in Prediction of Hepatocellular Carcinoma in Hepatitis CPatients Treated with Direct – Acting Antiviral Agents

1. Abstract1.1. Background: Hepatocellular Carcinoma (HCC) is the 6th most common malignancy globally and it’s the most common tumor which originates primarily in the liver, the aim of this study is to find out the connection between increased serum nitric oxide (sNO) and its HCC predictive value in patients who received direct-acting antiviral agents (DAAs).1.2. …

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Oropharyngeal Transition during Swallowing between Stroke and Head and Neck Cancer Survivors

1. Abstract 1.1. Objective: The purpose of this study was to analyze three oropharyngeal bolus transition timings, Oral Transition Time (OTT), Pharyngeal Transition Time (PTT), and Duration of Upper Esophageal Sphincter Opening (DUESO), using videofluoroscopic swallowing examinations (VFSEs) between stroke survivors and head and neck cancer survivors to determine differences between the two populations. 1.2. …

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Impact of Surgical Staging for Aggressive Histology Rectal Cancers – A Retrospective Review

1. Abstract 1.1. Introduction: Poorly Differentiated Adenocarcinomas (PDAC) and Signet ring adenocarcinomas (SRAC) are aggressive histologic subtypes of rectal cancer with high incidence of imaging occult peritoneal metastasis. 1.2. Methods: Retrospective review of aggressive histology, rectal cancer patients who underwent pre-treatment surgical staging as part of ovarian transposition or ostomy creation for diversion at a …

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The Influence of Pre-Treatment with a Proton Pump Inhibitor / H2 Receptor Antagonists on Helicobacter Pylori Eradication

1. Abstract Vonoprazan (VPZ) is more useful than proton pump inhibitor (PPI)-based regimen as H. pylori eradication therapy. It is controversial whether pretreatment with H2 receptor antagonist (H2RA) or PPI before H. pylori eradication treatment increases or decreases the eradication rate. In this retrospective study, 802 patients with H. pylori infection were treated. DOI:http://dx.doi.org/10.47829/JJGH.2020.5201