Research Article

Drug-induced liver injury (DILI) is a serious issue faced by the pharmaceutical industry, and often leads to drug withdrawal once patients experience drug-induced severe hepatic failure. We developed an in vitro assay system that enables to assess cellular damage and immune reaction responses that ultimately result in DILI using troglitazone as a model drug….

To study the application of adjuvant chemotherapy in the treatment of Perihilar cholangiocarcinoma (pCCA). We retrospectively collected the data of 86 patients who underwent surgery for perihilar cholangiocarcinoma in our department between 2012 to 2017. The patients were divided into surgery alone group (n=44) and adjuvant….

To explore the variables which could predict the prognosis and might be considered as staging factors in patients with T2N0M0 Esophageal Squamous Cell Carcinoma (ESCC).Records of 525 patients with pathologic T2N0M0 ESCC who underwent surgical resection were reviewed. The T2 category was further subdivided into T2a (circular muscle layers) and T2b (longitudinal muscle layers)….

Postoperative pancreatitis complications can be separated into two main groups based on literature reviews and clinical trials. Some authors suggest that postoperative pancreatitis is a severe complication that should be treated conservatively and operatively if needed. Other authors defend an opposite opinion that only postoperative hyperamylasemia exists, which is a transitory condition with no risk …

Immunological Pathways in the Development of Postoperative Hyper- amylasemia and Postoperative Pancreatitis Read More »

The symptoms of asthma and gastroesophageal reflux disease are similar making it difficult to distinguish. Diagnosing Gastroesophageal Reflux Disease (GERD) is complex, as it frequently presents with other pulmonary disease or conditions. Asthma has often been associated with gastroesophageal reflux disease…

A nocturnal leg cramps (NLC) is caused by a continuous, involuntary, painful, and localized contraction of a muscle or simply some muscle bundles.NLC is associated with a reduced quality of sleep and a subsequent lower health related quality of life. The purpose of our study is to clarify both prevalence and characteristics of NLC in …

Prevalence of Nocturnal Leg Cramps in Patients with Liver Disease is Higher than with Other Chronic Disease Read More »

In this study, we examined the relationship between the expression of Fas/Fas ligand apoptotic signaling pathway and pancreatic fibrosis in autoimmune chronic pancreatitis of aly/aly mice. The histopathological changes of inflammatory cell infiltration in pancreatitis aly/ aly mice were observed. Immunohistochemistry was used to detect the expression of CD4, CD8, CD45R/B220, F4, Fas/Fas ligand, collagen …

The Relationship between Pancreatic Fibrosis and Pancrea- tic Cell Apoptosis Induced by Fas/Fas Ligand Pathways in Aly/Aly Mice Read More »

Achalasia is a primary esophageal motility disorder characterized by the absence of esophageal peristalsis and impaired relaxation of the Lower Esophageal Sphincter (LES) in response to swallowing. The annual incidence of achalasia is approximately 1.6 per 100,000 individuals worldwide and prevalence of 10 cases per 100,000 individuals. Patients present usually with progressive dysphagia to solids …

The Endoscopic Combo Technique: Long-Term Outcomes in Treating Patients with Primary Achalasia Read More »

To eradicate Helicobacter Pylori (HP) infection it’s necessary to use at least two antibiotics. In patients infected with HP resistant to two or three antibiotics, eradication is more difficult. The objective of this study was to evaluate the efficacy of bismuth quadruple therapy (BQT)-10 days (omeprazole, bismuth, tetracycline-TET, and metronidazole-MTZ) for the eradication for HP …

Quadruple with Omeprazole, Bismuth, Tetracycline and Metroni- dazole Therapy for the Eradication of Helicobacter Pylori: Efficacy in Naive and Previously Treated Patients with Double and Triple Antimicrobial Resistance Read More »

Direct-Acting Antivirals (DAAs) have revolutionized the management of hepatitis C infection. However, genotype 3 cirrhosis is still difficult to treat. We report our experience in the management of geno- type 3 cirrhosis with DAA’s. We analysed 111 adult cirrhotics with genotype 3 infection of which 54 (48.6%) had Decom- pensated Cirrhosis (DC). Patients with Compensated