Research Article

Drug Repurposing for Inflammatory Bowel Disease Based On Relations Among Drugs, Diseases and Genes

1. Abstract Drug repurposing, which treats new and other diseases utilizing existing drugs, has turned into a much-valuable strategy. It can also be referred to as re-examination of existing drugs that have failed to indicate utility for new diseases. In this work, we mainly focused on finding inflammatory bowel disease (IBD) associated drugs based on …

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Acute Pancreatitis as First Manifestation of Severe Hypothyroidism: A Rare Case Report

1. Abstract We described the case of a 34-year-old Bangladeshi man with an unremarkable personal and family history who presented to the emergency department with severe upper abdominal pain of one day’s duration and with elevated serum amylase and lipase. Further work-up revealed a serum triglyceride level of 39.8 mmol/L and his thyroid function test …

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Anti Hcv Antibody Merits Proper Interpretation

1. Abstract 1.1. Introduction: Chronic Hepatitis C Virus (HCV) infection, a leading cause of liver cirrhosis, causes significant morbidity and mortality and has become an important indication for liver transplantation all over the world. The initial treatment was with Pegylated Interferon and Ribavarin but later on wide availability of oral Directly Acting Antiviral (DAA) drugs …

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Registry to Understand Patient Characteristics, Treatment Patterns, and Therapy Outcomes in Adults with Chronic Hepatitis C Virus Infection in Asia, Africa, and Eastern Europe

1. Abstract 1.1. Background: Several patient, government, payer, and provider-level barriers to Hepatitis C virus (HCV) treatment have been identified in regions like Asia, Africa, and the Commonwealth of Independent States (CIS). A patient registry was created in these regions to understand the patterns of clinical care and outcomes in real-world settings.

Self-expandable Metallic Stents for the Palliation of Malignant Growth of Esophagus

1. Abstract 1.1. Background: Often patients with carcinomas of esophagus presents with dysphagia at a late stage where curative treatments are not a treatment option. To relieve dysphagia and its consequences palliative esophageal stentings are offered. Self-expanding metal stents (SEMS) and self-expanding plastic stents (SEPS) are available for reliving the dysphagia. Uncovered, partially covered, or …

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Effects of Targeting NRF2 on Inhibiting Gastric Cancer Growth and Tumor Development in Vitro and in Vivo

1. Abstract 1.1. Background: Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a transcription factor that regulates the expression of the cellular antioxidant response. Traditionally, Nrf2 is regarded as a tumor suppressor owing to its characteristic which prevents oxidative or electrophilic insult. However, there is increasing evidence that Nrf2 is activated in malignant cells. At …

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Network Meta-Analysis of Hepatic Arterial Infusion Versus Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastasis

1. Abstract 1.1. Background: Colorectal cancer liver metastases (CRLM) that cannot be surgically removed are often addressed locally with Hepatic Arterial Infusion (HAI) or Selective Internal Radiation Therapy (SIRT). This study used Bayesian network meta-analysis (NMA) to assess the differences in survival between patients treated with HAI or SIRT for CRLM.