Research Article

Efficacy of Pemafibrate Against Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

1. Abstract 1.1. Background: Nonalcoholic fatty liver disease (NAFLD), one of the most common causes of chronic liver diseases, is characterized by chronic liver inflammation and fibrosis, which consequently promote cirrhosis and liver cancer. Pemafibrate, a selective PPARα modulator is a new lipid-lowering drug that provides better hypertriglyceridemia control compared to greater other fibrates without …

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Immunological Reason for Mild Affection of Children to COVID-19, A Key Factor for Novel Solution of Vaccination and Medications

1. Abstract Coronaviruses are important human and animal pathogens. We will show that probably antibodies don’t have essential role in immunity against COVID-19 in long term, but a type of white globules named T cells may have critical role in immunity against COVID-19. T cells have long time memory to remain in blood.

Microrna-145 Inhibits EMT and Fibrosarcoma Cell Proliferation, Migration and Invasion by Targeting HMGA2

1. Abstract 1.1 Aim: Fibrosarcoma is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth and a high rate of local recurrence. The participation of microRNAs (miRNAs/miRs) in the pathogenesis of human diseases and the vital role of miR-145 in different types of cancer. However, the role of miR-145 in fibrosarcoma remains …

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Effect of Antibiotics on The Gut Microbiota in Children with Chronic Pancreatitis

1. Abstract 1.1. Objectives: Little is known about the effect of antibiotic treatment on the gut microbiota in children with chronic pancreatitis (CCP). Our objective was to identify the effect of antibiotic treatment on the gut microbiota in children with chronic pancreatitis (CCP), the main gut microbiota genera and characterize the patients’ functional mutations after …

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Self-Expandable Metal Stents for the Management of Gastric Outlet Obstruction: Experience from A Tertiary-Care Facility in Pakistan

1. Abstract 1.1. Aim Gastric outlet obstruction is commonly considered as advanced malignancies of the stomach, duodenum, pancreas, hepatobiliary, and ampullary regions. Surgical bypass and chemotherapy are the common treatment modalities for gastric obstruction. This study was done to determine the outcomes of self-expandable metal stents in patients with gastric outlet obstruction. DOI : http://dx.doi.org/10.47829/JJGH.2021.7903

Intestinal Ischemia Following Cardiac Surgery: An Unusual Clinical Presentation

1. Abstract Mesenteric ischemia is a dreadful complication with a high mortality rate. Early diagnosis and management is mandatory to improve prognosis. We report a 72-year-old woman who has undergone a bioprosthetic aortic valve replacement. She presented an abdominal pain associated to an occlusive syndrome. Angio-CT scan has found initially a functional bowel obstruction without …

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Salvia Miltiorrhiza Ameliorates Disease Progression in Dextran-Sodium-Sulfate Induced Colitis in Mice

1. Abstract Salvia miltiorrhiza (SM, or Danshen) extract has been approved by China FDA for the treatment of cardiovascular and cerebrovascular diseases owing to its potent anti-inflammatory effects. Whether SM may be used to treat Inflammatory Bowel Disease (IBD) remains elusive. In the current study, Dextran-Sodium-Sulfate (DSS) induced colitis in mice was used as a …

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