Research Article

1. Abstract 1.1. Background During the last two decades, there is a constant search for new therapeutic options for colorectal cancer (CRC). We evaluated PubMed literature on CRC different treatment options during the past two decades. Special attention was attributed to specific treatment options according to biological markers.

1. Abstract Since the emergence of the SARS-CoV-2 induced COVID-19 pandemic, millions of patients have been diagnosed for the disease and many of them have died worldwide. SARS-CoV-2 has been undergoing genetic changes leading the disclosure of new variants. Since the unfolding of SARS-CoV-2, several recurrent mutations, particularly in the spike protein, emerge during human-to-human …

SARS-Cov-2: Interaction Between Mutations and Variants and Their Influence on Treatment and Preventive Strategies Read More »

1. Abstract 1.1. Background: Wilson disease (WD) is an autosomal recessive inherited disorder caused by homozygous or compound heterozygous mutations in the ATP7B gene. The ATP7B gene encodes trans-membrane copper-transporting ATPase 2, which mediates the excretion of copper into bile and delivers copper to the transporting protein ceruloplasmin in blood. The genetic database reported over …

Novel Variants Associated with Wilson Disease in Saudi Families Read More »

1. Abstract 1.1. Background: Hepatocellular carcinoma is one of the most common causes of cancer death. Prognosis of resected hepatocellular carcinoma has been a matter of debate with various staging system; the Japanese system and the system of Vauthey et al are two commonly used staging systems. We sought to validate these two systems using …

Hepatocellular Carcinoma: A Comparison Between Two Staging Systems for Respectable Tumors Read More »

1. Abstract 1.1. Objective: To investigate the clinical effect of the “five-step” laparoscopic right hepatectomy via the anterior approach on the treatment of hepatocellular carcinoma and summarize the experience. 1.2. Background: Right hepatectomy via the anterior approach has been used for hepatocellular carcinoma in many medical centers because of its advantages. However, due to the …

Laparoscopic Right Hepatectomy Via Anterior Approach: The Experience at a Single Center Read More »

1. Abstract 1.1. Aims: This study aimed to analyze recurrence-free survival (RFS), post-recurrence survival (PRS) based on ICC recurrence patterns and treatment modalities.

1. Abstract 1.1. Background: Extracellular vesicle derived-DNA (EV DNA) have emerged as attractive diagnostic biomarkers in diseases diagnosis, while its role in metastatic colorectal cancer (mCRC) is unknown. This study aimed to explore the role of EV DNA in monitoring of gene mutations related to drug resistance during therapy with the anti-EGFR antibody cetuximab.

1. Abstract 1.1. Background: Bariatric surgery is considered a life-saving intervention for treating morbid obesity. The overall reduction in caloric intake accompanied by reduced intake of proteins and several key nutrients, such as iron and vitamin B12 can severely affect various hematological markers, including hemoglobin, hematocrit, and RBC count. This study aimed to investigate the …

Hematological Changes post Bariatric Surgery in Saudi Arabia; Single Tertiary Care Center Experience Read More »

1. Abstract 1.1. Background: Advanced endoscopy, namely endoscopic retrograde cholangiopancreatography (ERCP), has an integral role in the diagnosis and management of patients with Inflammatory Bowel Disease (IBD). ERCP is frequently performed in this population to diagnose Primary Sclerosing Cholangitis (PSC) or to manage strictures. This study aims to evaluate ERCP-related AEs in IBD patients using …

Measure Twice, Cut Once: Appraising The Safety of ERCP in IBD Read More »

1. Abstract 1.1. Objective: Nonalcoholic Fatty Liver Disease (NAFLD) is the most important cause of hepatic steatosis and hypertransaminasemia in western countries. The objective was to evaluate the prevalence of NAFLD among a population of 261025 people in the East Valladolid public healthcare area in Spain.