Review Article

Quo Vadis Medicina Ex Testimoniis? Part 1. A Quarter Century after Its Inception, Where is Evidence-Based Medicine (EBM) Today? More Questions than Answers

Leave a Comment / Issue 3 Articles, Volume 5 / By admin

1. AbstractThe domain of ‘Evidence-based medicine’ (also known as ‘EBM’) is increasingly ubiquitous across the medical literature and experience. It is just about one generation old and worthy of further refinements.Five related insights are outlined here:Among others, clinical epidemiology, fundamental and field epidemiology and biostatistics have led to EBM. DOI: http://dx.doi.org/10.47829/JJGH.2020.5303

Acronymization of Evidence-Based and Other Medicines Anything Goes, or Should It?

Leave a Comment / Issue 3 Articles, Volume 5 / By admin

1. Abstract Evidence-Based Medicine is here to stay, and it is expanding, with evolving modifications, new topics, new research and teaching groups, and new recipients of information. Acronyms, as brief and condensed ways to present and understand ideas related to the above-mentioned phenomena, are also increasing in number and some, serious or funny, are worthy …

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Quo Vadismedicina Ex Testimoniis? A Quarter Century after its Inception, Where is Evidence-Based Medicine Now? More Questions than Answers

Leave a Comment / Issue 2 Article, Volume 5 / By admin

1. AbstarctTo mistrust science and deny the validity of the scientific method is to resign your job as a human. You’d better go look for work as a plant or wild animal. P.J. ORourke 1947- Parliament of Whores (1991).Just as Peter asked Jesus in the New Testament about two thousand years ago, Domine, quo vadis? …

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Putative Regulatory Element Located in the Introns 9 and 17 of the ACE2 Gene May Be Influenced By COVID-19 Risk Variants

Leave a Comment / Issue 2 Article, Volume 5 / By admin

1. Abstract Preliminary genomic data of the SARS-CoV2 virus responsible for COVID-19 showed that, its ability to infect relies on special cell surface spike proteins that have binding affinity to the human protein angiotensin-converting enzyme (ACE2). Among several patients analysed, it usually infects most age groups evenly. However, only a small percent of the confirmed …

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The Silence Eclipsing Introns

Leave a Comment / Issue 15 Article, Volume 4 / By admin

1. Abstract In spite of the deep insight that has been gathered hitherto in Molecular Genetics, a few obscurities are as challenging as they were. Among these, introns, with reference to its functionality, have been debated quite often. And many theories that have emerged following such grappling discussions have given believable explanations but have failed …

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Action of Cholera Toxin B Subunit and Peptide LKEKK on Different Cell Types

Leave a Comment / Issue 14 Articles, Volume 4 / By admin

1. Abstract The review analyzed and systematized data on the action of cholera toxin B subunit (CT- B) and the synthetic peptide LKEKK that corresponds to residues 16-20 in thymosin-? and 131-135 in interferon-?2 on the functional, NO-synthase and guanylate cyclase activ- ity of T and B lymphocytes, of macrophage-like cell line RAW 264.7, of …

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Principles of Cryopreservation and Applicabilities in Intestinal Organoids

Leave a Comment / Issue 11 Articles, Volume 4 / By admin

1. AbstractCryobiology is known as a study of low temperatures effects in tissues and cells, which means understand influences on decreasing temperature and pressure in the freezing medium and how the cell membrane reacts to these variables. Cryopreservation emerged by the principles of Cryo- biology as a technology capable of preserving the composition and viability …

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Portal Vein Trombosis: Literature Review and a Case Report

Leave a Comment / Issue 11 Articles, Volume 4 / By admin

1. AbstractPortal Vein Thrombosis (PVT) is an unusual complication in patients with liver cirrhosis. In current research on genesis, it has been demonstrated an underlying prothrombotic state and a combination of local endothelial factors, family and/or acquired inheritance, in addition to other thrombophilic factors.

Gastrointestinal and Liver Involvement in COVID-19: A Roadmap from Early Identification to Treatment

Leave a Comment / Issue 10 Articles, Volume 4 / By admin

1. Abstract December 2019 has brought another historical pandemic which has posed a serious threat to global health. As of 24th August 2020, 23 311719 confirmed cases and of 806410 deaths have been reported due to this most challenging disease of the 20th century so far, named as coronavirus disease 2019 (COVID-19).

Bcl-2 and SIRT3 Affect Tumor Cell Viability by Integrating Metabolism and Apoptosis

Leave a Comment / Issue 9 Articles, Volume 4 / By admin

While apoptotic tolerance caused by B cell lymphoma 2 (Bcl-2) over expression is one of the important underlying mechanisms of the decreased apoptotic sensitivity of tumor cells, only tar- geting Bcl-2 as an anticancer therapy has shown limited clinical benefit, which may be related to the non-apoptotic protective effects of Bcl-2, such as its roles …

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