Short Communication

Clinical Relevance of Bile Acid and their Conjugates in Health and Disease

1. Short Communication Bile Acids (BA) are synthesized by the oxidation of cholesterol in the liver and secreted into the duodenum. BAs were circulated from the duodenum back to the liver by enterohepatic recirculation. BAs regulate many physiological functions, including the expression of genes involved cholesterol, glucose, and their homeostasis. BAs have several pathologic effects, …

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Pros and Cons of Iron Deficiency and Iron Deficiency Anaemia

1. Short Communication Iron deficiency anaemia (IDA) and iron deficiency (AD) are very common specially in low-income countries [1]. People can suffer from symptoms of anaemia in the absence of anaemia itself if they have decreased iron stores as red blood cells and tissue will not receive enough iron from the plasma when iron stores …

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Enhancing A Radiomics-Based Pathological Response Prediction for Locally Advanced Rectum Cancer

1. Abstract 1.1. Aims: This study aims to further enhance a validated radiomics-based model for predicting pathologic complete response (pCR) after chemo‑radiotherapy (CRT) in LARCs for use in the clinical practice. 1.2. Methods: A generalized linear model (GLM) to predict pCR in LARC patients previously trained in Europe and validated with external inter-continental cohort (59 …

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Post Pandemic Challenges for Cancer Service Provision, The Need for A Fitting Strategy, A Standpoint from The UK

1. Short Communication Soon after the 1st lockdown was imposed in the UK on March 27, 2020, all elective activity surgical and endoscopic stopped in James Cook University Hospital, Cleveland County in North of England. It was almost a standstill due to fear of the unknown and senior upper GI oncology surgeon, thinking how one …

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Methylprednisolone Decrease In – Hospital Mortality in Patients with COVID-19 Pneumonia

1. Short Communication Acute respiratory distress can occur in patients with COVID-19 disease due to viral replication of SARS-COV-2 and an uncontrolled immune inflammatory reaction. We compared the efficacy of intravenous methylprednisolone and intravenous dexamethasone on mortality rate in severe COVID-19 patients with pneumonia and hypoxemia using the new 4C mortality score on admission and …

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Menghini Needles are Superior to Tru-Cut Needles for Blind Percutaneous Liver Biopsy in Children

1. Abstract 1.1. Background: Liver biopsy remains the criterion standard in the evaluation of the etiology and extent of disease of the liver. Various needles are available for use, depending on the approach and on physician experience. 1.2. Methods: We used in our service for three years Menghini needles and the last year Tru- cut …

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Is HIV in the Human Population Since the Beginning of our Existence?

Despite great success in the diagnostics and therapy of AIDS, there are many unanswered questions. Without giving the answers to these questions more successful treatment of patients cannot be expected. The strong argument for this prediction is a fact that it is not possible to stop the worldwide spread of AIDS, especially in Africa. The …

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Are we Close to Achieving HBV Cure? Risk for Hepatocellular Carcinoma Persists Despite Successful Suppression of Hepatitis B Virus for Over a Decade

FSince the discovery of the Hepatitis B Surface Antigen [1] and recognition of the antigen linked with post-transfusion hepatitis by the same group and others, significant progress on our understanding of the Hepatitis B Virus (HBV) has followed. Such advances include the illustration of the HBV virion [2], identification of Hepatitis B e-Antigen [3]