Research Article

1. Abstract 1.1. Aims DBPR108 is an orally active dipeptidyl peptidase 4 (DPP-4) inhibitor in animals. The present first-in-human randomized, double-blind, and placebo-controlled study evaluated DBPR108 for safety and tolerability in healthy adult Asian male volunteers. 1.2. Main Methods DBPR108 were orally given at 25-600 mg as single and multiple once-daily doses for 8 consecutive …

DBPR108, A Dipeptidyl Peptidase-4 Inhibitor for Treatment of Type 2 Diabetes Mellitus: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Single and Multiple Doses in Healthy Volunteers Read More »

1. Abstract 1.1. Objectives: Pyroptosis is a type of programmed cell death that has been discovered and confirmed in recent years, which were characterized by pro-inflammatory and is related to tumor progression, prognosis and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear. At the same time, …

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration Read More »

1. Abstract 1.1. Background: Constipation is a common condition. Lactulose & Polyethylene Glycol (PEG) are effective & safe, recommended as first-line medication for Chronic Constipation (CC). 1.2. Aim: To compare the efficacy and safety of PEG 3350 versus lactulose in patients with CC. 1.3. Methods: In this single-center, randomised, open label, parallel-group study. Patients with …

Comparative Efficacy and Safety of Polyethylene Glycol vs Lactulose in Chronic Constipation: Non Inferiority Study Read More »

1. Abstract Alanine transaminase ALT is considered the most specific marker for hepatocellular membrane damage, once asymptomatic ALT elevation may be the only indicator of some liver diseases such as non-alcoholic fatty liver disease NAFLD which is the most common liver disease in the western world, so it is necessary to define upper limit of …

Upper Limit of Normal Serum Alanine Transaminase ALT and Correlation with Gender and BMI Read More »

1. Abstract 1.1. Background: Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related death. Due to the poor prognosis of standard treatment, it is urgent to evaluate the immune molecular characteristics and find new HCC immune biomarkers and immunotherapy . The homeostasis of polyamines is closely related to tumor progression and prognosis. The …

Identification of Polyamine Subtypes in Hepatocellular Carcinoma and Characteristics of their Immune Infiltrates Read More »

1. Abstract 1.1. Aims: To investigate the correlation between severity and pathological features of Drug-Induced Liver Injury (DILI), and the independent factors of pathological features affecting the severity of the disease were explored.

1. Abstract 1.1. Background: Ampullary cancer is of particular classificatory interest as it may arise either from the intestinal epithelium or the epithelium covering the pancreatobiliary ducts knows as Intestinal type (IT) and Pancreatobiliary type (PBT) respectively. These 2 histological subtypes have different clinical characteristics, in terms of disease stage, recurrence rates and survival. Immuno …

Role of Immunohistochemically Typing in Pancreaticobiliary and Intestinal Type Differentiation of Periampullary Adenocarcinomas Read More »

1. Abstract 1.1. Introduction: It is important to determine the epidemiological factors like etiology, age, sex, mode of clinical presentation of fatty liver and development of complications like chronic liver disease, so as to design optimal and cost effective preventive and treatment strategies for the same.

1. Abstract 1.1. Introduction: Hepatitis B Virus (HBV) infection is a global problem with nearly 350 million chronic carriers, who are at risk of liver cirrhosis & hepatocellular carcinoma. Over 50% of these carriers are believed to have acquired their infection vertically from their mothers, i.e. through mother – to – Child Transmission (MTCT). Vertically …

Effective Strategies for Preventing Vertical Transmission in Hepatitis B Read More »

1. Abstract 1.1. Background and Aim The epidemiology, clinical characteristics, natural course, and treatment of Inflammatory Bowel Disease (IBD) in the gastroenterology centres of Al Kharj, Riyadh Province, are still largely unknown. Therefore, a survey was conducted to describe IBD features to correlate the findings with published data from the rest of the country and …

Inflammatory Bowel Disease in a Central Rural Area, Riyadh Province Al-Kharj of Saudi Arabia: Epidemiology, Clinical Characteristics, Natural Course of Disease and Current Clinical Practice Read More »