Immune Profile of Severe Refractory Crohn’s Disease Patients Candidates to Autologous Hematopoietic Stem Cell Transplantation
1. Abstract Crohn’s disease is a chronic relapse – remitting inflammatory bowel disease with a wide range of incapacitating symptoms, and significant health care costs. The complex pathophysiology of Crohn’s disease is not always solved by conventional and biologic therapies and thus, some patients evolve with severe refractory disease. T and B cells reacting to …